Tris(hydroxymethyl) Methyl Aminomethane THAM
Structural Formula
Molecular formula: C4H11NO3
Chinese name: Tris(hydroxymethyl)aminomethane
English name: Tris(hydroxymethyl)methyl aminomethane THAM
English another name: Tris base; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; THAM; Trometamol
CAS number: 77-86-1
Molecular formula: C4H11NO3
Linear molecular formula: NH2C(CH2OH)3
Molecular weight: 121.14
Purity: ≥99.5%
EC number: 201-064-4
Properties: White crystalline particles.
Density: 1,353 g/cm3
Chemical properties: soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride, corrosive to copper and aluminum, and irritating.
Processing Method
A method for preparing tris(hydroxymethyl)aminomethane, the specific preparation steps are as follows:
(1) Add the trimethylolmethane to the methanol aqueous solution, heat to 50-70°C and stir to dissolve, wherein the mass-volume ratio of the trimethylolmethane to the methanol aqueous solution is 8:3-7 in g/ml , The methanol aqueous solution is prepared by mixing pure water and methanol in a volume ratio of 2:3;
(2) Add charcoal activated carbon to the solution, wherein the weight ratio of the charcoal activated carbon to trimethylolmethane is 0.5-2:100, keep it at 45-55°C for 20-40 minutes, filter it while the Chemicalbook is hot, and collect the filtrate ；
(3) Concentrate the filtrate under reduced pressure at a concentration temperature of 70-80°C, until crystals appear, let it cool down;
(4) After the crystals are separated by suction filtration, rinse with absolute ethanol and dry at 40-60°C for 3-5 hours to obtain.
The above-mentioned preparation method of tris, the obtained tris has high purity, which meets the requirement of the benchmark reagent for the purity of tris, and the process is stable and reasonable, which is especially suitable for the production of kilogram batch products. The process is simple and reasonable, and the product qualification rate is high, which is suitable for the needs of large-scale industrial production.
Purpose
Mainly used in pharmaceutical intermediates and biochemical reagents. Intermediate of fosfomycin, also used as vulcanization accelerator, cosmetics (cream, lotion), mineral oil, paraffin emulsifier, biological buffer, biological buffer Agent.
Storage Method
Store in a cool, dry and well-ventilated warehouse. Keep away from fire and heat sources.
